Tag: Mike Magee

Feeling the Pressure

Apr 7, 2025

By MIKE MAGEE

After Trump crashed the markets, citizens worldwide are “feeling the pressure.” But in the spirit of calming us down, let’s consider a story of human cooperation and success from our past.

It has been estimated that a medical student learns approximately 15,000 new words during the four years of training. One of those words is sphygmomanometer. the fancy term for a blood pressure monitor. The word is derived from the Greek σφυγμός sphygmos “pulse”, plus the scientific term manometer (from French manomètre).

While medical students are quick to memorize and learn to use the words and tools that are part of their trade, few fully appreciate the centuries-long efforts to advance incremental insights, discoveries, and engineering feats that go into these discoveries.

Most students are familiar with the name William Harvey. Without modern tools, he deduced from inference rather than direct observation that blood was pumped by a four chamber heart through a “double circulation system” directed first to the lungs and back via a “closed system” and then out again to the brain and bodily organs. In 1628, he published all of the above in an epic volume, De Motu Cordis.

Far fewer know much about Stephen Hales, who in 1733, at the age of 56, is credited with discovering the concept of “blood pressure.” A century later, the German physiologist, Johannes Müller, boldly proclaimed that Hales “discovery of the blood pressure was more important than the (Harvey) discovery of blood.”

Modern day cardiologists seem to agree.

The World’s Psychoactive Drug of Choice

Apr 4, 2025

By MIKE MAGEE

Question: What is the world’s most widely used psychoactive drug?

Answer: Caffeine

In the U.S., caffeine is consumed mainly in the form of coffee, tea, and cola. But coffee dominates. Worldwide, humans consume over 10 million tons of coffee beans a year. Roughly 16% (1.62 million tons) is devoured by Americans. The daily intake of caffeine varies depending on type of beverage and brand as the chart below indicates.

On average, each American consumes approximately 164 mg of caffeine each day. That’s roughly 1 small cup of Dunkin or (3.5) 12-ounce Diet Cokes (Trump consumes at least 12 cans of Diet Coke a day).

Across the globe, daily consumption of caffeine is close to universal. Eight in 10 humans consume a caffeinated beverage daily. That makes this chemical substance the “most commonly consumed psychoactive substance globally.” Its popularity is related to its ability to deliver three useful physiological enhancements – wakefulness, motor performance, and cognition.

Chemically, caffeine is a close cousin of adenosine which is present in brain neurons. Adenosine builds up in synaptic connections between brain neurons. When it binds to special receptors, it activates neurons that promote sleepfulness. Ingested caffeine is water and lipid soluble, and therefore is able to traverse the blood-brain barrier. Once inside, its chemical structure mimics that of adenosine, and it occupies adenosine receptors because it shares the same approximate shape and size. When these receptors are occupied by caffeine, adenosine molecules are unable to activate the receptors. The net effect is wakefulness.

Emory, Balloon Angioplasty, and the Musk Attack on Medical Diplomacy

Mar 28, 2025

By MIKE MAGEE

“The recently announced limitation from the NIH on grants is an example that will significantly reduce essential funding for research at Emory.”

Gregory L. Fenes, President, Emory University

In 1900, the U.S. life expectancy was 47 years. Between maternal deaths in child birth and infectious disease, it is no wonder that cardiovascular disease (barely understood at the time) was an afterthought. But by 1930, as life expectancy approached 60 years, Americans stood up and took notice. They were dropping dead on softball fields of heart attacks.

Remarkably, despite scientific advances, nearly 1 million Americans ( 931,578) died of heart disease in 2024. That is 28% of the 3,279,857 deaths last year.

The main cause of a heart attack, as every high school student knows today, is blockage of one or more of the three main coronary arteries – each 5 to 10 centimeters long and four millimeters wide. But at the turn of the century, experts didn’t have a clue. When James Herrick first suggested blockage of the coronaries as a cause of heart seizures in 1912, the suggestion was met with disbelief. Seven years later, in 1919, the clinical findings for “myocardial infarction” were associated with ECG abnormalities for the first time.

Scientists for some time had been aware of the anatomy of the human heart, but it wasn’t until 1929 that they actually were able to see it in action. That was when a 24-year old German medical intern in training named Werner Forssmann came up with the idea of threading a ureteral catheter through a vein in the arm into his heart.

His superiors refused permission for the experiment. But with junior accomplices, including an enamored nurse, and a radiologist in training, he secretly catheterized his own heart and injected dye revealing for the first time a live 4-chamber heart. Two decades would pass before Werner Forssmann’s “reckless action” was rewarded with the 1956 Nobel Prize in Medicine. But another two years would pass before the dynamic Mason Sones, Cleveland Clinic’s director of cardiovascular disease, successfully (if inadvertently) imaged the coronary arteries themselves without inducing a heart attack in his 26-year old patient with rheumatic heart disease.

But it was the American head of all Allied Forces in World War II, turned President of the United States, Dwight D.Eisenhower, who arguably had the greatest impact on the world focus on this “public enemy #1.” His seven heart attacks, in full public view, have been credited with increasing public awareness of the condition which finally claimed his life in1969.

Cardiac catheterization soon became a relatively standard affair. Not surprisingly, less than a decade later, on September 16, 1977, an East German physician, Andreas Gruntzig performed the first ballon angioplasty, but not without a bit of drama.

Dr. Gruntzig had moved to Zurich, Switzerland in pursuit of this new, non-invasive technique for opening blocked arteries. But first, he had to manufacture his own catheters. He tested them out on dogs in 1976, and excitedly shared his positive results in November that year at the 49th Scientific Session of the American Heart Association in Miami Beach.

He returned to Zurich that year expecting swift approval to perform the procedure on a human candidate. But a year later, the Switzerland Board had still not given him a green light to use his newly improved double lumen catheter. Instead he had been invited by Dr. Richard Myler at the San Francisco Heart Institute to perform the first ever balloon coronary artery angioplasty on an awake patient.

Gruntzig arrived in May, 1977, with equipment in hand. He was able to successfully dilate the arteries of several anesthetized patients who were undergoing open heart coronary bypass surgery. But sadly, after two weeks on hold there, no appropriate candidates had emerged for a minimally invasive balloon angioplasty in a non-anesthetized heart attack patient.

In the meantime, a 38-year-old insurance salesman, Adolf Bachmann, with severe coronary artery stenosis, angina, and ECG changes had surfaced in Zurich. With verbal assurances that he might proceed, Gruntzig returned again to Zurich. The landmark procedure at Zurich University Hospital went off without a hitch, and the rest is history.

Is American Apartheid Lurking in The Oval Office Shadows?

Mar 14, 2025

By MIKE MAGEE

For aging Boomers, it is impossible not to hear echoes of Apartheid re-emerging with force 3/4 of a century after the battle for social justice here and in far away lands was fully engaged. The Musk assault, disguised as “efficiency” is little more than stealing money from the poor to give to the rich, and widens an already extraordinary income gap.

The assault is large enough to draw condemnation from a dying Pope Francis, forced to remind Trump, Musk and their enablers of the historic Jesus and the tenets of Liberation Theology.

Our college years in the 1960’s were accompanied by chaos and crisis, and guided by fundamental Judeo-Christian values. My college, the Jesuit-led Le Moyne College, was activist to its core. The movement was championed by two priests, brothers Daniel and Philip Berrigan. With the assassinations of JFK, his brother Robert, and MLK; LBJ’s Great Society legislative battles; the Civil Rights movement; and the Vietnam War, America was literally on fire at the time.

It was during this decade as well that a largely student-driven movement emerged to oppose Apartheid in South Africa and rapidly spread worldwide. A seminal feature of that movement was mass education and demonstrations with a goal of creating economic pressure on the leaders of South Africa by divestiture of all stocks and investments that benefited the nation.

Disruption For the Sake of Disruption Is Not Innovation

Feb 18, 2025

By MIKE MAGEE

“The technological leaps of the 1900s — microelectronics, antibiotics, chemotherapy, liquid-fueled rockets, Earth-observing satellites, lasers, LED lights, disease-resistant seeds and so forth — derived from science. But these technologies also spent years being improved, tweaked, recombined and modified to make them achieve the scale and impact necessary for innovations.” Jon Gertner, author of “The Idea Factory.”

The Idea Factory is a history of Bell Labs, spanning six decades from 1920 to 1980. Published a decade ago, the author deliberately focused on the story inside the story. As he laid out his intent, Jon Gertner wrote “…when the drive to invent has become a mantra, Bell Labs offered us a way to enrich our understanding of the challenges and solutions to technological innovation. Here, after all, was where the foundational ideas on the management of innovation were born.”

One of the scholars Gertner likes to reference is Clayton Christensen. As a professor at Harvard Business School, he coined the term “disruptive innovation.” The Economist magazine loved him, labeling him in 2020 “the most influential management thinker of his time.”

A process thinker, Christensen deconstructed innovation, exploring “how waves of technological change can follow predictable patterns.” Others have come along and followed in his steps.

Identify a technologic advance with a potential functional market niche.
Promote its appeal as a “must have” to users.
Drop the cost.
Surreptitiously push aside or disadvantage competitors.
Manage surprises.

Medical innovations often illustrate all five steps, albeit not necessarily in that order. Consider the X-ray. Its discovery is attributed to Friedrich Rontgen (Roentgen), a mechanical engineering chair of Physics at the University of Wurzburg. It was in a lab at his university that he was exploring the properties of electrically generated cathode rays in 1896.

He created a glass tube with an aluminum window at one end. He attached electrodes to a spark coil inside the vacuum tube and generated an electrostatic charge. On the outside of the window opening he placed a barium painted piece of cardboard to detect what he believed to be “invisible rays.” With the charge, he noted a “faint shimmering” on the cardboard. In the next run, he put a lead sheet behind the window and noted that it had blocked the ray-induced shimmering.

Not knowing what to call the rays, he designated them with an “X” – and thus the term “X-ray.” Two weeks later, he convinced his wife to place her hand in the line of fire, and the cardboard behind. The resultant first X-ray image (of her hand) led her to exclaim dramatically, “I have seen my death.” A week later, the image was published under the title “Ueber eine neue Art von Strahlen” (On A New Kind of Rays).

Who Will Oppose American Apartheid?

Feb 3, 2025

By MIKE MAGEE

This past month Bishop Mariann E. Budde drew the Episcopal Church into the national spotlight through a single act of courage. She is not the first, nor likely the last from this denomination to do so. There is a history. More on that in a moment.

The Episcopal church is an offshoot of the Anglican Church of England which dates back to 1534 when King Henry VIII broke with the Catholic Pope who opposed his marriage to Anne Boleyn. Two-hundred and fifty four years later, in 1789, Anglican Church leaders who had helped settle colonies in North America, gathered to form a united Episcopal Church, revising their Book of Common Prayer to exclude its blessing to the English monarch.

Though declining in modern times, missionary minded Anglicans spread throughout the British empire and remain connected to the mother Church as members of the Anglican Communion. For example, British Anglican military chaplains were part of the force that occupied Cape Colony in South Africa in 1795. By 1821, they had established a formal religious foothold. Today, they claim 3.5 million members. In 2012, they elected their first female bishop, Ellinah Wamukoya of Swaziland. And yet, arguably the most influential female Anglican from South Africa is an immigrant to America, an emotional ally of Bishop Budde, and a retired Chief Justice of the Massachusetts Supreme Court.

Her name is Margaret Marshall, and her place in American history dates back to June 6, 1966. That was the date this then 20 year old student, who was vice-president of the National Union of South African Students, was asked to stand in for the organization’s president, Ian Robertson (who was under house arrest for speaking out about Apartheid). She met and transported Bobby Kennedy to speak to over 1000 university students packed into the college auditorium at their “Day of Affirmation.”

Much like Mariann Budde last week in Washington, Bobby Kennedy caught his hushed audience by surprise that evening with these opening remarks:

“I come here this evening because of my deep interest and affection for a land settled by the Dutch in the mid-seventeenth century, then taken over by the British, and at last independent; a land in which the native inhabitants were at first subdued, but relations with whom remain a problem to this day; a land which defined itself on a hostile frontier; a land which has tamed rich natural resources through the energetic application of modern technology; a land which was once the importer of slaves, and now must struggle to wipe out the last traces of that former bondage. I refer, of course, to the United States of America.”

Margaret Marshall, some six decades later, recalled that moment in a conversation with Doris Kearns Goodwin. She said, “There was great tension in the room. People were on edge…As soon as the audience realized what he said, there was laughter and a sense of total relief. It was simply fabulous.”

All The Way With LBJ – A Half Century After His Passing

Jan 23, 2025

By MIKE MAGEE

This is the 52nd anniversary of the death of Lyndon Baines Johnson from his 5th Heart Attack. And two days ago was the 39th anniversary of the first celebration of a new federal holiday, Martin Luther King Jr. Day. In signing that original proclamation in 1983, President Ronald Reagan said, “The majesty of his message, the dignity of his bearing, and the righteousness of his cause are a lasting legacy. In a few short years he changed America for all time.”

The MLK federal holiday was not so “Kum ba yah” (“Come by here”) this year. President Trump was in no mood to be tutored on this 60’s phrase derived from an African American spiritual made famous by Pete Seeger. Rather, he took advantage of the convergence of MLK’s day and his own coronation to trash all things DEI (Diversity, Equity, Inclusion).

Of those supporting the 2nd term President, from here and beyond, few could have had a broader smile on his face than dearly departed (July 4, 2008) former North Carolina Senator Jesse Helms. Helm led the opposition to the MLK bill, submitting a 300-page report that labelled King an “action-oriented Marxist” and a communist. Senator Daniel Patrick Moynihan (NY) was so enraged at the time that he declared the report a “packet of filth”, threw it on the Senate floor, and then unceremoniously repeatedly stomped on it.

So, as a nation, we have been down this road before.

Sleep: Watch This Space

Jan 17, 2025

By MIKE MAGEE

In case you’ve missed it, sleep is all the rage in neurosciences these days. They are fast at work rebranding it “the brain’s rinse cycle.” The brain, protectively encased in an unyielding bony casing, lacks the delicate lymphatic system that transports used body metabolites to breakdown and extraction sites in all other parts of the body.

But in 2012, neuroscientist Maiken Nedergaard, identified a unique network of delicate channels (“tiny passages alongside blood vessels”) inside the brain that collect and discharge brain metabolites and waste materials including amyloid. This system, or “ultimate brainwasher” as some labeled it, was formally titled the “glymphatic system.”

That same study also suggested that flow through the glymphatic system is enhanced during portions of the sleep cycle. Now 12 years after the original research, the same team, in a study in mice published in the Proceedings of the National Academy of Sciences USA journal, found that regular contractions or oscillations of tiny blood vessels in the brain, stimulated by adrenaline cousin, norepinephrine, generated the brain scrubbing liquid flow through the channel system. The focal contractions, normally occurring ever 50 seconds, speed up the pump to every 10 seconds, in sync with peaks of norepinephrine release during sleep.

Sleep deprivation appears to not only interrupt this cycle, and allow harmful wastes to accumulate, but also disrupts other mental health functions that scientists are just beginning to understand. For example, researchers in 2021 established that “sleep deprivation impairs people’s ability to suppress unwanted thoughts.” They were able to identify a special location on the brain cortex responsible for storing away memories, and suppressing and delaying their future retrieval. They further demonstrated enhanced activity at the site during REM sleep. As the lead investigator noted, “That’s interesting because many disorders associated with debilitating intrusive thoughts, such as depression and PTSD, are also associated with disturbances in REM.”

The new work may help explain destructive recycling of historic conflicts among and between Silicon Valley AI uber-competitors. They may not be getting enough sleep, recycling historic grudges and grievances.

As the sleep scientists reported in the December, 2024 publication, “The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.”

Mike Magee MD is a Medical Historian and regular contributor to THCB. He is the author of CODE BLUE: Inside America’s Medical Industrial Complex. (Grove/2020)

Past Presidents Posthumous Advice To Trump #47

Jan 10, 2025

By MIKE MAGEE

For those many, many millions of viewers who tuned in to the live coverage of former President Jimmy Carter’s funeral this week, they were rewarded with two hours of intriguing video images, and moving words and song, including a recounting of the beginnings of environmental advocacy as Los Angeles burns, and John Lennon’s “Imagine” performed by Garth Brooks and Trisha Yearwood.

Five former Presidents and four Vice-Presidents were in attendance. And there were notable firsts, like the first greeting and handshake between incoming President Trump and former VP Pence since January 6, 2021.

But perhaps the most striking events of this carefully staged national funeral were the two especially haunting posthumous eulogies delivered by the sons of a former president and vice-president. Presented by Steven Ford, son of former President, Gerald Ford, and Ted Mondale, son of former Vice-President Walter “Fritz” Mondale, they appeared to be directed to America itself, and its’ soon-to-be 47th president.

As the speakers explained, Jimmy Carter, some years back, asked both Ford and Mondale if they would be willing to present eulogies at his funeral. Both agreed, and put pen to paper in anticipation. But as it became evident that Carter might very well outlive them, they each asked their sons, in that event, to read their remarks at his funeral. And today they did.

Both President Ford and Vice-President Mondale’s words (voiced by their sons) deserve a full viewing when time allows. But in the meantime, let me share the closing remarks of each, prescient and timely now, at American democracy’s hour of need.

Steven Ford, son of former President Gerald Ford (7/14/13 – 12/26/06), reciting the president’s written words posthumously:

“…Now is time to say goodbye, our grief comforted with the joy and the thanksgiving of knowing this man, this beloved man, this very special man. He was given the gift of years, and the American people and the people of the world will be forever blessed by his decades of good works. Jimmy Carter’s legacy of peace and compassion will remain unique as it is timeless…As for myself, Jimmy, I’m looking forward to our reunion. We have much to catch up on. Thank you, Mr. President. Welcome home, old friend.”

Ted Mondale, son of former Vice-President Walter “Fritz” Mondale (1/5/28 – 4/19/21) reciting the vice-president’s written words posthumously.

Ted prefaced his reading with this sentence – “My father wrote this in 2019, and clearly he edited it a number of times since then, but here we go.”

“…Two decades ago, President Carter said he believed income inequality was the biggest global issue. More recently, in a 2018 Commencement Address at Liberty University, I think now the largest global issue is the discrimination against women and girls in this world. He concluded that, ‘Until stubborn attitudes that foster discrimination against women change, the world cannot advance, and poverty and poverty and income equality cannot be solved.’ Towards the end of our time in the White House, the President and I were talking about how we might describe what we tried to accomplish in office. We came up with a sentence which remains an important summary of our work. ‘We told the truth. We obeyed the law. And we kept the peace.’ That we did, Mr. President. I will always be proud and grateful to have had the chance to work with you towards noble ends. It was then, and will always be, the most rewarding experience of my public career. Thank you.”

Mike Magee MD is a Medical Historian and regular contributor to THCB. He is the author of CODE BLUE: Inside America’s Medical Industrial Complex. (Grove/2020)

Public Health Policy: At the Intersection of Law and Medicine.

Jan 6, 2025

By MIKE MAGEE

As 2025 kicks off, it’s wise to pause, and gather our thoughts as a nation. Few would argue that we’ve been through a lot over the past decade. And quite naturally, we humans are prone to blame individuals rather than circumstances (most of which have been beyond our control) for creating an environment that feels as if it is unraveling before our eyes.

How should we describe our condition – dynamic, tense, complex? Is peace, contentment, and security achievable in this still young nation? Have accelerationist technocrats, armed with bitcoins and Martian fantasy, short-circuited our moment in time that had been preserved for recovery from a deadly pandemic that eliminated a million of our fellow citizens seemingly overnight?

Who do we turn to for answers, now that we’ve largely lost faith and trust in our politicians, our religious leaders, and our journalists? And how exactly do you create a healthy nation? Certainly not by taking doctors and nurses offline for miscarriages, and placing local bureaucrats in exam rooms. Are they prepared to deal with life and death decisions? Are they trained to process human fear and worry? Do they know how to instill hopefulness in parents who are literally “scared to death” because their child has just been diagnosed with cancer? It certainly must require more than a baseball cap with MAHA on it to heal this nation.

Historians suggest this will take time. As Stanford Professor of Law, Lawrence M. Friedman, wrote in A History of American Law, “One hundred and sixty-nine years went by between Jamestown and the Declaration of Independence. The same length of time separates 1776 and the end of World War II.”

During those very early years that preceded the formal declaration and formation of the United States as a nation, our various, then British colonies, fluidly and independent of each other, did their best first to survive, and then to organize into shared communities with codified laws and regulations. It was “a study of social development unfolding over time” impacted by emotions, politics and real-time economics. At the core of the struggle (as we saw with the pandemic, and now the vaccine controversy) was a clash between the rights of the individual and those of the collective community.

This clash of values has been playing out in full view over the past five years of the Covid pandemic. In 2023, Washington Post columnist, Dr. Leana Wen, asked, “Whose rights are paramount? The individual who must give up freedoms, or those around them who want to lower infection risk?”