The goal of the new non profit Ten Ten Ten founded by TJ Tedesco & Bhargav Raman is to take America from being the most expensive health system in the world with the 48th best outcomes to the top Ten in outcomes, at 10% of GDP in Ten years. Are they crazy? Is there any hope of doing this? I spent a long time in conversation with them suggesting that they probably are, but it was a great conversation to hear why they are doing this and how they think we might do this–Matthew Holt
Carta Healthcare – AI for Registry Creation
It’s not well known but there’s a lot of people in hospitals who spend a lot of time creating patient registries for quality programs, CMS reporting, clinical trials and lots more. It requires extremely detailed abstraction of patient data from patient records and comparisons with registry demands. Wouldn’t it be clever if an AI system could read the chart and help the people doing that work (usually very expensive nurses) do it quicker? That’s the premise behind Carta Healthcare. Greg Miller and Jared Crapo from Carta demoed the system for me and told me about the market for it–Matthew Holt
Jim Gallic shows off Wondr Health
Jim Gallic is Chief Growth Officer at Wondr Health, a company specializing in creating the behavior change required for weight loss. He was a satisfied client who lost a ton of weight (see that before and after photo on the right!) and changed his eating habits completely using Wondr (no drugs involved!). Later in life he joined the company. I spoke to him and got a tour of the experience. A great demo about how Wondr works, and about how GLP1s are altering the conversation. Jim’s stance is that the behavior change works first to create a readiness program for the medication, and then the weight might stay off when the medication ends. Matthew Holt
Travis Rush & Kala Weeks, Reperio
Reperio Health is trying to really boost the delivery of at home health testing, including not only weight and blood pressure but also cholesterol, obesity and blood sugar. Having use the kit and done an at home demo, I’m pretty interested to see if this can be a front-end telehealth service to get the average middle aged adult into a preventative health checkup. (Here was my experience)
I spent some time at the HLTH conference back in October talking with Travis Rush, CEO and Kala Weeks, VP Marketing to discuss how it works, who they are targeting and what their metrics are. And how they think this will roll out — Matthew Holt
Katie D’Amico, Carequest–Integrating Oral Health into Medical Care
Katie D‘Amico is the VP of Innovation at Carequest, a non-profit that supports oral health–she’s a big proponent on its integration with medical care. At HLTH in October 2025 she took me on a brief tour of innovation in dental care and oral health. We had a quick look at the ability to test collagen breakdown and how to use the dental office to refer to lab tests. I also had a brief chat with Dr Ashley Lerman from Firstgrin, which is helping kids take care of their teeth, and distributing her kits and apps via health plans and hospitals–Matthew Holt
Nabla — It’s been a rocketship
I met the Nabla management team two years ago. Two years later they have ridden the wave of AI scribing to be one of the leaders in the field. At HLTH this year, I caught up with CEO Alex Lebrun and COO Delphine Groll to check in on their growth (150 customers and 100K users) what the next little bit of ambient AI scribing will look like (more specialties, more integration) and whether they’re scared of Epic (no!).–Matthew Holt
Sachin Jain–How do we do better?
What are the practices that we have normalized that future generations will criticize us for? Sachin Jain, CEO of SCAN Health Plan, is perhaps the leading truth teller in health care who also runs a real health care organization. I had a really fun but serious interview with Sachin about what health care people are doing, what are the bad things that happen. How are good people letting this happen? How we should be changing what we are doing?–Matthew Holt
Kai Romero, Evidently
Kai Romero is Head of Clinical Success at Evidently. The company is one of many that are using AI to dive into the EMR and extract data to deliver it to clinicians. It works to get really great information from the EMR to various flavors of clinicians in a fast and innovative way. Kai leads me on a detailed exploration of how the technology gets used as a layer over the EMR. And Kai shows me the new version that allows and LLM to deliver immediate answers from the data. This is a demo you really need to see to understand how AI is changing, and improving, that clinical experience. Meanwhile Kai is fascinating. She was an ER doc who became a specialist in hospice. We didn’t get into that too much, but you can tell about her input into Evidently’s design — Matthew Holt
Justin Schrager demos Vital.io
Justin Schrager is the CMO of Vital.io. Their technology sits in the hospital telling patients what is going on with their care while they are in the hospital, particularly in the ER. Justin showed a deep demo about the patient experience of using Vital.io which includes what the patient can expect and guides them through the confusing workflow. It allows the patient to make requests, and also lots of guidance about what is happening to them, or for example what lab results might mean. It goes as far as helping people book appointments for follow up with the right doctor. We had a great chat about the product and also about the realities of running a tech company that has to integrate with Epic and many other EMRs.–Matthew Holt
Greg Whisman, CareMore Health
Greg Whisman is the Chief Medical Officer of CareMore Health, a venerable prepaid medical group caring for seniors. It’s been part of Anthem/Elevance for many years but this year spun off as part of a larger PE backed group called Millennium. We really got into the what and the how of primary care for seniors and, yes, we delved deep into the future of primary care. This is a topic that will never die on THCB and getting a real expert to opine on it was really valuable. This is a great conversation–Matthew Holt
