New Interventions Needed to Halt the Growth of “Superbugs”

How do you tell the family members of a critically ill patient that their loved one is going to die because there are no antibiotics left to treat the patient’s infection?  In the 21st century, doctors are not supposed to have to say things like this to patients or their families.

Ever since the discovery of penicillin in 1940, patients have expected a pill or an intravenous injection to cure their infections. But our hubris as a society with respect to antibiotics has been exposed by the rise of antibiotic-resistant “superbugs.”

The Centers for Disease Control and Prevention (CDC) recently issued a new study, entitled “Antibiotic resistance threats in the United States, 2013,” reporting that at least 2 million people become infected with bacteria that are highly resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. These estimates are highly conservative.  Many more people die from other conditions that were complicated by an antibiotic-resistant infection.

Meantime, we have ever-decreasing new weapons to wage the war against such infections because the availability of new antibiotics is down by more than 90% since 1983.

Interventions are needed to encourage investment in new antibiotics, to prevent the infections in the first place, to slow the spread of resistance and to discover new ways to attack microbes without driving resistance.

A major reason for the “market failure” of antibiotics is that they are taken for short periods of time, so they have a lower return on investment than drugs that are taken for years (such as cholesterol-lowering drugs).  The Food and Drug Administration can help reverse the market failure by adopting new regulatory approaches to encourage development of critically needed new antibiotics.

First, though, our worldview of antibiotics and bacteria needs to change.  We have to learn that antibiotics are a limited resource that can be exhausted if we do not act to preserve and restore them. Controlling the misuse of antibiotics can slow the spread of antibiotic resistance. But it cannot stop it.

Resistance is inevitable, and efforts to preserve the antibiotic resource must be matched by efforts to restore it.

Reducing resistance will require a comprehensive societal effort.  Healthcare systems can work to improve the health of populations and efficiency of care to reduce hospital admissions, improve infection prevention efforts and reduce unnecessary antibiotic prescriptions, all of which will decrease infections and antibiotic use, slowing antibiotic resistance. We should also ban antibiotic use to promote the growth of livestock, which accounts for a staggering 80% of total antibiotic use in the US.

New methods for disinfection and new approaches to treating infections caused by bacteria also must be discovered. Novel approaches could include trying to modify bacteria’s ability to cause disease, or trying to alter how humans respond to bacteria, without seeking to kill the bacteria.

A complete overhaul of the approaches to resistance, disease and prevention could change the continuing upward trajectory of antibiotic resistant infections. To do anything less invites a bleak “post-antibiotic” future, in which infectious diseases once again reign supreme.

Brad Spellberg, MD, an infectious disease specialist at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, is the author of the book, “Rising Plague: The Global Threat from Deadly Bacteria and Our Dwindling Arsenal to Fight Them.”

4 replies »

  1. Hi, thanks for this perspective. Big Pharma constitutes one third of the equation. The second “third” is willingness of medical establishment to give antibiotic rather than other approaches (amputate early, drain abscess, cut off infective portions) probably due to common concerns about aesthetics and disfigurement, quality of life. The third set in the responsibility triangle belongs to the caregiving community. We hospital nurses know- physicians are more likely to read off orders over the phone, perhaps drop in for a quick few minutes, or abdicate their personal interest to another intensivist/hospitalist. We view mixtures of irrationally used antibiotics-some for organisms that are resistant! Physicians!! Pay attention to your patients! Families and patients: pay attention to the medications being used! Nurses and other LIPs: stop the use of antibiotics by questioning them along with infection prevention,.

  2. Thanks, Dr. Spellberg. Great, informative article!

    I’m curious if you think a contest/prize is a viable path towards incenting pharma to go after the next big antibiotic. I’ve seen that idea tossed out before but don’t know what the reaction was like from their end.

  3. An important point but one that I think many people are largely tuning out – I think there’s a lot of “yes, yes I get there is a problem here – I’d really love to do something but I’m too busy to think about this – I’ll let somebody else deal with it and feel vague feelings of guilt ”

    You mention the built in “market failure” hypothesis as a reason pharmas are spending less time on this and suggest a new approach from FDA could be the answer. Can you tell us a little more about your idea here?