The use of marijuana is associated with a marked increase in the risk of being involved in severe trauma particularly motor vehicle collisions. In 2009, for instance, marijuana use was a contributing factor in more than 460,000 emergency department visits in the United States.
But we also know that cannabis is potentially neuroprotective. Previous studies have found that tetrahydrocannabinol (THC), the active ingredient in marijuana, may have beneficial effects in certain types of neurodegenerative processes, like Alzheimer’s and Huntington’s disease. In addition, previous studies indicate THC may protect the brain in animal models of neurologic injury. However, clinical trials of a synthetic THC derivative were not ultimately associated with an increase in survival in patients with traumatic brain injury. Since overall findings were mixed, we hypothesized that use of the “native” form of THC could be associated with an increase in survival in patients with traumatic brain injury.